Acetaminophen
4'-Hydroxyacetanilide
p-Acetylaminophenol
N-(4-Hydroxyphenyl) acetamide
C8H9NO2 / HOC6H4NHCOCH3
Molecular mass: 151.2
ICSC # 1330
CAS # 103-90-2
RTECS # AE4200000
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Types of Hazard/ Exposure
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Acute Hazards/ Symptoms
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Prevention
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First Aid/
Fire Fighting
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FIRE
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Combustible.
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NO open flames.
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Powder, alcohol-resistant foam, water spray, carbon dioxide.
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Explosion
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Exposure
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PREVENT DISPERSION OF DUST!
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•Inhalation
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Cough.
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Local exhaust or breathing protection.
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Fresh air, rest.
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•Skin
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Protective gloves.
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Rinse and then wash skin with water and soap.
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•Eyes
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Redness.
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Safety goggles
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Rinse with plenty of water (remove contact lenses if easily possible).
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•Ingestion
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Do not eat, drink, or smoke during work.
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Give one or two glasses of water to drink.
: 300-500 ml of water (ref. 37);
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Spillage Disposal
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Storage
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Packaging & Labelling
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Personal protection: particulate filter adapted to the airborne concentration of the substance.
Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting.
Do NOT let this chemical enter the environment.
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Provision to contain effluent from fire extinguishing.
Store in an area without drain or sewer access.
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Signal: Warning
Health haz
May cause damage to liver and kidneys through prolonged or repeated exposure if swallowed.
Toxic to aquatic life
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Important Data
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Physical State; Appearance:
COLOURLESS CRYSTALS
OR CRYSTALLINE POWDER
Physical Dangers:
Chemical Dangers:
Occupational Exposure Limits:
TLV not established.
MAK not established.
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Routes of Exposure:
The substance can be absorbed into the body
by ingestion.
Inhalation Risk:
A nuisance-causing concentration of airborne particles can be reached quickly.
Effects of Short-Term Exposure:
ity- after ingestion of 10-15 g (140-250 mg/kg) (ref 27),29,37,40;
Effects of Long-Term or Repeated Exposure:
The substance may have effects on the kidneys and liver
, resulting in impaired functions,
when ingested.
13813100
e been detected in experimental animals but may not be relevant to humans. Peer review 11/98.; 13839000
w 11/98. chromatid breaks in peripheral human blood lymphocytes in vivo (ref. 8,25), incr. genotoxic damage in man (ref.30),34, other: not expected to cause heritable damage in man (ref.41); 13859000
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Physical
Properties
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Boiling point: >500°C
Melting point: 169-170°C
Density: 1.3
g/cm3
Solubility in water, g/100 ml at 20°C: 1.4
(moderate)
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Relative vapour density (air = 1): 5.2
Auto-ignition temperature: 540°C
Explosive limits, vol% in air: 15 - ?
Octanol/water partition coefficient as log Pow: 0.49
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Environmental
Data
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The substance is toxic to aquatic organisms.
It is strongly advised that this substance does not enter the environment.
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N O T E S
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n 24h of overdose - nausea, vomiting, lethargy; within 24-48h to 3-4d-first indication of liver damage;
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ADDITIONAL INFORMATION
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ICSC: 1330
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PARACETAMOL
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(C) IPCS, CEC, 1994
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IMPORTANT LEGAL NOTICE:
Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH,
the CEC or the IPCS is responsible for the use which might be made of this
information. This card contains the collective views of the IPCS Peer Review Committee and may
not reflect in all cases all the detailed requirements included in national legislation
on the subject. The user should verify compliance of the cards with the relevant legislation
in the country of use.
The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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