2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
Ethrane
Ether, 2-chloro-1,1,2-trifluoroethyl difluoromethyl
C3H2ClF5O / CHF2OCF2CHClF
Molecular mass: 184.50
ICSC # 0887
CAS # 13838-16-9
RTECS # KN6800000
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Types of Hazard/ Exposure
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Acute Hazards/ Symptoms
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Prevention
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First Aid/
Fire Fighting
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FIRE
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Not combustible.
Gives off irritating or toxic fumes (or gases) in a fire.
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In case of fire in the surroundings: use appropriate extinguishing media.
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Explosion
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Exposure
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•Inhalation
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Cough.
Sore throat.
Drowsiness.
Weakness.
Unconsciousness.
See Notes.
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Ventilation, local exhaust, or breathing protection.
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Fresh air, rest.
Artificial respiration may be needed.
Refer for medical attention.
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•Skin
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Redness.
Dry skin.
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Protective gloves.
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Remove contaminated clothes.
Rinse skin with plenty of water or shower.
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•Eyes
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Redness.
Pain.
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Safety spectacles,
or eye protection in combination with breathing protection.
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First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
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•Ingestion
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(See Inhalation).
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Do not eat, drink, or smoke during work.
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Rinse mouth.
Refer for medical attention.
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Spillage Disposal
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Storage
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Packaging & Labelling
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Ventilation.
Collect leaking and spilled liquid in sealable containers as far as possible.
Absorb remaining liquid in sand or inert absorbent and remove to safe place.
(Extra personal protection: self-contained breathing apparatus).
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Keep in a well-ventilated room.
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Important Data
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Physical State; Appearance:
COLOURLESS LIQUID
, WITH CHARACTERISTIC ODOUR.
Physical Dangers:
The vapour is heavier than air
and may accumulate in lowered spaces causing a deficiency of oxygen.
Chemical Dangers:
The substance decomposes
on heating
producing
toxic and corrosive fumes
(
hydrogen chloride
,
hydrogen fluoride
).
Attacks some
plastic
and
rubber
.
Occupational Exposure Limits:
TLV: 75 ppm as TWA; A4; (ACGIH 2002).
MAK: 20 ppm;
Peak limitation category: II(8); Pregnancy risk group: C;
(DFG 2002).
OSHA PEL: none
NIOSH REL*: C 2 ppm (15.1 mg/m3) 60-minute *Note: REL for exposure to waste anesthetic gas.
NIOSH IDLH: N.D. See: IDLH INDEX
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Routes of Exposure:
The substance can be absorbed into the body
by inhalation of its vapour
and
by ingestion.
Inhalation Risk:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
Effects of Short-Term Exposure:
The substance
is irritating to
the eyes
,
the skin
and
the respiratory tract
.
The substance may cause effects on the
central nervous system
and
cardiovascular system
.
Exposure at high levels may result in unconsciousness.
Effects of Long-Term or Repeated Exposure:
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Physical
Properties
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Boiling point: 56.5°C
Relative density (water = 1): 1.52
Solubility in water: poor
Vapour pressure, kPa at 20°C: 23.3
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Relative vapour density (air = 1): 1.9
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.12
Explosive limits, vol% in air: 4.25-?
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Environmental
Data
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N O T E S
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Other names: Anesthetic compound no. 347, NCS-115944, Alyrane, Efrane, Ohio 347.
Other CAS numbers: (+)-enflurane CAS 22194-21-4; (-)-enflurane CAS 22194-22-5.
Check oxygen content before entering area.
High concentrations in the air cause a deficiency of oxygen with the risk of unconsciousness or death.
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ADDITIONAL INFORMATION
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ICSC: 0887
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ENFLURANE
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(C) IPCS, CEC, 1994
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IMPORTANT LEGAL NOTICE:
Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH,
the CEC or the IPCS is responsible for the use which might be made of this
information. This card contains the collective views of the IPCS Peer Review Committee and may
not reflect in all cases all the detailed requirements included in national legislation
on the subject. The user should verify compliance of the cards with the relevant legislation
in the country of use.
The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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