Phosphonothioic acid, phenyl-, O-ethyl O-(4-nitrophenyl) ester
O-Ethyl O-4-nitrophenyl phenyl phosphonothioate
C14H14NO4PS
Molecular mass: 323.3
ICSC # 0753
CAS # 2104-64-5
RTECS # TB1925000
UN # 2783
EC # 015-036-00-2
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Types of Hazard/ Exposure
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Acute Hazards/ Symptoms
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Prevention
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First Aid/
Fire Fighting
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FIRE
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Combustible.
Liquid formulations containing organic solvents may be flammable.
Gives off irritating or toxic fumes (or gases) in a fire.
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NO open flames.
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Powder, alcohol-resistant foam, water spray, carbon dioxide.
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Explosion
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Exposure
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PREVENT DISPERSION OF DUST!
STRICT HYGIENE!
AVOID Exposure OF ADOLESCENTS AND CHILDREN!
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IN ALL CASES CONSULT A DOCTOR!
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•Inhalation
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Dizziness.
Pupillary constriction, muscle cramp, excessive salivation.
Sweating.
Muscle twitching.
0,33;
ds;
3;
00
sequence (NOT on card): 17125, 17143, 17129, 17142, 17127, 17131, 17119, 17114, 17137;
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Local exhaust or breathing protection.
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Fresh air, rest.
Half-upright position.
Artificial respiration may be needed.
Refer immediately for medical attention.
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•Skin
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MAY BE ABSORBED!
Redness.
Pain.
(Further See Inhalation).
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Protective gloves.
Protective clothing.
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Remove contaminated clothes.
Rinse and then wash skin with water and soap.
Refer immediately for medical attention.
Wear protective gloves when administering first aid.
Put clothes in sealable container (SEE Notes).
soluble in water;
tion;
0 skn-rat:25 mg/kg (ref.11);
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•Eyes
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Redness.
Blurred vision.
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Face shield,
or eye protection in combination with breathing protection if powder.
Safety spectacles
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Rinse with plenty of water (remove contact lenses if easily possible).
Refer immediately for medical attention.
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•Ingestion
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Nausea.
Abdominal cramps.
Vomiting.
Diarrhoea.
Drowsiness.
(Further see Inhalation).
dy diarrhea),25,26,30;
sness (ref.30);
eathing.
an (ref.5,21)
onstriction, muscle cramps, excessive salivation.
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Do not eat, drink, or smoke during work.
Wash hands before eating.
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Rinse mouth.
Give a slurry of activated charcoal in water to drink.
Refer immediately for medical attention.
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Spillage Disposal
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Storage
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Packaging & Labelling
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Personal protection: complete protective clothing including self-contained breathing apparatus.
, bioacumulation used
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Separated from strong oxidants,food and feedstuffs.
Well closed.
Provision to contain effluent from fire extinguishing.
Store in an area without drain or sewer access.
to aquatic organisms;
45
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Do not transport with food and feedstuffs.
Severe marine pollutant.
T+ symbol
N symbol
R: 27/28-50/53
S: 1/2-22-36/37-45-60-61
UN Hazard Class: 6.1
UN Packing Group: I
Signal: Danger
Skull-Health haz-Enviro
Fatal if swallowed
Fatal if inhaled
Fatal in contact with skin
Causes damage to the nervous system
Very toxic to aquatic life with long-lasting effects
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Important Data
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Physical State; Appearance:
LIGHT YELLOW CRYSTALLINE POWDER
, WITH CHARACTERISTIC ODOUR.
dour (ref. 11,26);
Physical Dangers:
Chemical Dangers:
The substance decomposes
on heating
producing toxic and corrosive fumes
including
,
nitrogen oxides
,
phosphorus oxides
sulfur oxides.
Reacts with strong oxidants
causing fire and explosion hazard.
The substance decomposes
under the influence of
bases
producing p-nitrophenol (see ICSC 0066).
1,26;
Occupational Exposure Limits:
TLV: 0.1 mg/m3 as TWA
(Inhalable fraction;)
(skin); BEI issued; A4 (not classifiable as a human carcinogen); (ACGIH 2008).
MAK: 0.05 mg/m3 (Inhalable fraction);
Pregnancy risk group: D; Peak limitation category: II(2);
skin absorption (H); (DFG 2008).
percutaneous absorption
OSHA PEL: TWA 0.5 mg/m3 skin
NIOSH REL: TWA 0.5 mg/m3 skin
NIOSH IDLH: 5 mg/m3 See: 2104645
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Routes of Exposure:
The substance can be absorbed into the body
by inhalation of its aerosol,
through the skin and
by ingestion.
kin: 25 mg/kg (ref.11); 25-230 mg/kg (ref.5, 13);
at oral: 7.7 mg/kg; 36 mg/kg (ref.11,13), 14.5-91 mg/kg (ref.5);
Inhalation Risk:
A harmful concentration of airborne particles can be reached quickly.
Effects of Short-Term Exposure:
The substance
is irritating to
the eyes
and
the skin.
Cholinesterase inhibitor.
The substance may cause effects on the nervous system
, resulting in convulsions, respiratory failure.
Exposure may result in unconsciousness or death.
The effects may be delayed.
Medical observation is indicated.
burns),28,39;
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(oral lethal dose in humans: 0.3 gramsr (70 kg) (ref. 30).;
Effects of Long-Term or Repeated Exposure:
Cholinesterase inhibitor; cumulative effect is possible: see acute hazards/symptoms.
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Physical
Properties
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Boiling point at 0.667 kPa: 215°C
Melting point: 36°C
Density: 1.3 g/cm3
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Solubility in water: none
Vapour pressure, Pa at 25°C: < 0.01
Octanol/water partition coefficient as log Pow: 4.78
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Environmental
Data
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The substance is very toxic to aquatic organisms.
Bioaccumulation of this chemical may occur in fish.
The substance may cause long-term effects in the aquatic environment.
This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal.
g Kow:4.48 (ref.26,24), BCF: 358-7,700 in fish, moderate bioconc., non-bidegrad. (ref.42);
nce may be hazardous to the environment; special attention should be given to honey bees, birds. (ref.39);
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N O T E S
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Depending on the degree of exposure, periodic medical examination is indicated.
Isolate contaminated clothing by sealing in a bag or other container.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Do NOT take working clothes home.
Transport Emergency Card: TEC (R)-61GT7
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ADDITIONAL INFORMATION
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ICSC: 0753
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EPN
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(C) IPCS, CEC, 1994
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IMPORTANT LEGAL NOTICE:
Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH,
the CEC or the IPCS is responsible for the use which might be made of this
information. This card contains the collective views of the IPCS Peer Review Committee and may
not reflect in all cases all the detailed requirements included in national legislation
on the subject. The user should verify compliance of the cards with the relevant legislation
in the country of use.
The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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