2-Bis(2-chloroethyl)amino
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
C7H15Cl2N2O2P
Molecular mass: 261.1
ICSC # 0689
CAS # 50-18-0
RTECS # RP5950000
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Types of Hazard/ Exposure
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Acute Hazards/ Symptoms
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Prevention
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First Aid/
Fire Fighting
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FIRE
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Combustible.
Gives off irritating or toxic fumes (or gases) in a fire.
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NO open flames.
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Powder, water spray, foam, carbon dioxide.
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Explosion
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Exposure
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PREVENT DISPERSION OF DUST!
AVOID ALL CONTACT!
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IN ALL CASES CONSULT A DOCTOR!
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•Inhalation
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See Ingestion.
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Closed system and ventilation.
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Fresh air, rest.
Refer for medical attention.
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•Skin
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Redness.
Pain.
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Protective gloves.
Protective clothing.
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Remove contaminated clothes.
Rinse skin with plenty of water or shower.
Refer for medical attention.
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•Eyes
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Redness.
Pain.
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Face shield,
or eye protection in combination with breathing protection.
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First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
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•Ingestion
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Diarrhoea.
Dizziness.
Headache.
Nausea.
Vomiting.
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Do not eat, drink, or smoke during work.
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Rinse mouth.
Induce vomiting (ONLY IN CONSCIOUS PERSONS!).
Refer for medical attention.
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Spillage Disposal
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Storage
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Packaging & Labelling
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Consult an expert!
Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting.
Carefully collect remainder,
then remove to safe place.
(Extra personal protection: P3 filter respirator for toxic particles).
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Separated from
food and feedstuffs
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See Chemical Dangers.
Dry.
Keep in the dark.
Well closed.
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Important Data
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Physical State; Appearance:
FINE, WHITE, ODOURLESS CRYSTALLINE POWDER
(MONOHYDRATE). LIQUEFIES ON LOSS OF ITS WATER OF CRYSTALLIZATION.
TURNS DARK ON Exposure TO LIGHT.
Physical Dangers:
Chemical Dangers:
The substance decomposes
on burning
producing
toxic fumes
including
phosphorus oxides
and
nitrogen oxides
.
Occupational Exposure Limits:
TLV not established.
MAK not established.
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Routes of Exposure:
The substance can be absorbed into the body
by inhalation of its aerosol,
and
by ingestion.
Inhalation Risk:
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.
Effects of Short-Term Exposure:
The substance
is irritating to
the eyes,
the skin
and
the respiratory tract.
The substance may cause effects on the blood, bladder, central nervous system and heart.
Effects of Long-Term or Repeated Exposure:
The substance may have effects on the blood, bladder, lungs and bone marrow
, resulting in leucopenia, cystitis, pulmonary fibrosis.
This substance is carcinogenic to humans.
May cause heritable genetic damage in humans.
Does cause serious reproductive toxicity in humans.
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Physical
Properties
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Melting point: (monohydrate) 41-45°C
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Solubility in water, g/100 ml: 4
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Environmental
Data
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N O T E S
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The substance is combustible but no flash point is available in literature.
Depending on the degree of exposure, periodic medical examination is suggested.
Do NOT take working clothes home.
Endoxan, Mitoxan, Genoxal, Procytox, Sendoxan, Cytophosphan are trade names.
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ADDITIONAL INFORMATION
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ICSC: 0689
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CYCLOPHOSPHAMIDE
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(C) IPCS, CEC, 1994
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IMPORTANT LEGAL NOTICE:
Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH,
the CEC or the IPCS is responsible for the use which might be made of this
information. This card contains the collective views of the IPCS Peer Review Committee and may
not reflect in all cases all the detailed requirements included in national legislation
on the subject. The user should verify compliance of the cards with the relevant legislation
in the country of use.
The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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