Phosphoric acid trimethyl ester
Trimethyl orthophosphate
C3H9O4P / (CH3O)3PO
Molecular mass: 140.1
ICSC # 0686
CAS # 512-56-1
RTECS # TC8225000
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Types of Hazard/ Exposure
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Acute Hazards/ Symptoms
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Prevention
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First Aid/
Fire Fighting
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FIRE
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Combustible.
Gives off irritating or toxic fumes (or gases) in a fire.
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NO open flames.
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Alcohol-resistant foam,
dry powder,
carbon dioxide
water spray
.
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Explosion
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Exposure
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AVOID ALL CONTACT!
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•Inhalation
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Cough.
Sore throat.
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Ventilation, local exhaust, or breathing protection.
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Fresh air, rest.
Refer for medical attention.
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•Skin
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Redness.
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Protective gloves.
Protective clothing.
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Remove contaminated clothes.
Rinse skin with plenty of water or shower.
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•Eyes
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Redness.
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Safety goggles.
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First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
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•Ingestion
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Shortness of breath.
Weakness.
Hyperirritability. Tremors.
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Do not eat, drink, or smoke during work.
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Rinse mouth.
Induce vomiting (ONLY IN CONSCIOUS PERSONS!).
Refer for medical attention.
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Spillage Disposal
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Storage
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Packaging & Labelling
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Ventilation.
Collect leaking and spilled liquid in sealable containers as far as possible.
Absorb remaining liquid in sand or inert absorbent and remove to safe place.
Personal protection:
chemical protection suit including self-contained breathing apparatus.
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Separated from
strong oxidants,
strong bases.
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Important Data
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Physical State; Appearance:
COLOURLESS LIQUID.
Physical Dangers:
Chemical Dangers:
The substance decomposes
on burning
producing
toxic fumes
including
phosphorous oxides
.
Reacts
with
strong bases
and
strong oxidants
.
May explode on heating during large scale atmospheric pressure distillation.
Occupational Exposure Limits:
TLV not established.
MAK: skin absorption (H);
Carcinogen category: 3B; Germ cell mutagen group: 2;
(DFG 2004).
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Routes of Exposure:
The substance can be absorbed into the body
by inhalation of its vapour,
through the skin
and
by ingestion.
Inhalation Risk:
No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C.
Effects of Short-Term Exposure:
The substance
is irritating to
the eyes
,
the skin
and
the respiratory tract
.
The substance may cause effects on the nervous system.
Effects of Long-Term or Repeated Exposure:
The substance may have effects on the nervous system
, resulting in flaccid paralysis.
May cause heritable genetic damage to human germ cells.
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Physical
Properties
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Boiling point: 197.2°C
Melting point: -46°C
Relative density (water = 1): 1.2
Solubility in water, g/100 ml at 25°C: 50
(good)
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Vapour pressure, kPa at 20°C: 0.11
Flash point: 107°C
Octanol/water partition coefficient as log Pow: -0.52 and -0.78
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Environmental
Data
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N O T E S
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ADDITIONAL INFORMATION
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ICSC: 0686
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TRIMETHYL PHOSPHATE
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(C) IPCS, CEC, 1994
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IMPORTANT LEGAL NOTICE:
Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH,
the CEC or the IPCS is responsible for the use which might be made of this
information. This card contains the collective views of the IPCS Peer Review Committee and may
not reflect in all cases all the detailed requirements included in national legislation
on the subject. The user should verify compliance of the cards with the relevant legislation
in the country of use.
The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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