2-Hydroxy-2-methyl propionitrile
2-Methyl-lactonitrile
2-Cyanopropan-2-ol
p-Hydroxyisobutyronitrile
(CH3)2C(OH)CN / C4H7NO
Molecular mass: 85.1
ICSC # 0611
CAS # 75-86-5
RTECS # OD9275000
UN # 1541
EC # 608-004-00-X
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Types of Hazard/ Exposure
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Acute Hazards/ Symptoms
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Prevention
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First Aid/
Fire Fighting
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FIRE
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Combustible.
Gives off irritating or toxic fumes (or gases) in a fire.
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NO open flames.
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Powder, AFFF, foam, carbon dioxide.
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Explosion
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Above 74°C explosive vapour/air mixtures may be formed.
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Above 74°C use a closed system, ventilation.
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In case of fire: cool drums, etc., by spraying with water but avoid contact of the substance with water.
Combat fire from a sheltered position.
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Exposure
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AVOID ALL CONTACT!
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IN ALL CASES CONSULT A DOCTOR!
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•Inhalation
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Convulsions.
Cough.
Dizziness.
Headache.
Laboured breathing.
Nausea.
Shortness of breath.
Unconsciousness.
Vomiting.
Irregular heartbeat, tightness in the chest.
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Closed system and ventilation.
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Fresh air, rest.
Half-upright position.
Artificial respiration may be needed.
Refer for medical attention.
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•Skin
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MAY BE ABSORBED!
Redness.
Pain.
(See Inhalation).
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Protective gloves.
Protective clothing.
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Rinse and then wash skin with water and soap.
Refer for medical attention.
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•Eyes
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Redness.
Pain.
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Face shield,
or eye protection in combination with breathing protection.
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First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
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•Ingestion
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Abdominal cramps.
Burning sensation.
Convulsions.
Unconsciousness.
(See Notes,
(see Inhalation).
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Do not eat, drink, or smoke during work.
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Rinse mouth.
Refer for medical attention.
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Spillage Disposal
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Storage
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Packaging & Labelling
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Sweep spilled substance into containers.
Carefully collect remainder,
then remove to safe place.
Do NOT let this chemical enter the environment.
Personal protection: complete protective clothing including self-contained breathing apparatus.
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Provision to contain effluent from fire extinguishing.
Separated from
strong bases,
acids,
water
,
food and feedstuffs
.
Well closed.
Keep in a well-ventilated room.
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Airtight.
Do not transport with food and feedstuffs.
Marine pollutant.
T+ symbol
N symbol
R: 26/27/28-50/53
S: 1/2-7/9-27-45-60-61
UN Hazard Class: 6.1
UN Packing Group: I
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Important Data
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Physical State; Appearance:
COLOURLESS
LIQUID
, WITH CHARACTERISTIC ODOUR.
Physical Dangers:
The vapour is heavier than air.
Chemical Dangers:
The substance decomposes rapidly
on heating or
on contact with
bases
or
water
producing highly toxic and flammable hydrogen cyanide (see ICSC 0492), and acetone (see ICSC 0087).
Reacts
violently with
acids
and
oxidants
causing fire and explosion hazard.
Occupational Exposure Limits:
OSHA PEL: none
NIOSH REL: C 1 ppm (4 mg/m3) 15-minute
NIOSH IDLH: N.D. See: IDLH INDEX
TLV: (as CN) 5 mg/m3 (Ceiling value); (skin); (ACGIH 2004).
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Routes of Exposure:
The substance can be absorbed into the body
by inhalation,
through the skin
and
by ingestion.
Inhalation Risk:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
Effects of Short-Term Exposure:
The substance
is irritating to
the eyes
,
the skin
and
the respiratory tract
.
The substance may cause effects on the
cardiovascular system
and
central nervous system
, resulting in
asphyxia
,
cardiac disorders
,
convulsions
,
cyanosis
and
respiratory failure
.
Exposure may result in death.
Medical observation is indicated.
See Notes.
Effects of Long-Term or Repeated Exposure:
The substance may have effects on the central nervous system and thyroid
, resulting in
impaired functions
.
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Physical
Properties
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Boiling point: 95°C
Melting point: -19°C
Relative density (water = 1): 0.93
Solubility in water: freely soluble, but decomposes in water
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Vapour pressure, kPa at 20°C: 3.0
Relative vapour density (air = 1): 2.93
Flash point: 74°C c.c.
Explosive limits, vol% in air: 2.2-12
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Environmental
Data
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The substance is very toxic to aquatic organisms.
Avoid release to the environment in circumstances different to normal use.
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N O T E S
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The occupational exposure limit value should not be exceeded during any part of the working exposure.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Hazard and toxicity of this substance is due to its major metabolite - hydrogen cyanide (see ICSC 0492).
Card has been partly updated in October 2004 and 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response.
Transport Emergency Card: TEC (R)-61S1541
NFPA Code: H4; F1; R2
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ADDITIONAL INFORMATION
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ICSC: 0611
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ACETONE CYANOHYDRIN
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(C) IPCS, CEC, 1994
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IMPORTANT LEGAL NOTICE:
Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH,
the CEC or the IPCS is responsible for the use which might be made of this
information. This card contains the collective views of the IPCS Peer Review Committee and may
not reflect in all cases all the detailed requirements included in national legislation
on the subject. The user should verify compliance of the cards with the relevant legislation
in the country of use.
The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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