Dimethylformamide
DMF
DMFA
N-Formyldimethylamine
C3H7NO / HCON(CH3)2
Molecular mass: 73.09
ICSC # 0457
CAS # 68-12-2
RTECS # LQ2100000
UN # 2265
EC # 616-001-00-X
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Types of Hazard/ Exposure
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Acute Hazards/ Symptoms
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Prevention
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First Aid/
Fire Fighting
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FIRE
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Flammable.
Gives off irritating or toxic fumes (or gases) in a fire.
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NO open flames, NO sparks, and NO smoking.
NO contact with oxidants.
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Powder, alcohol-resistant foam, water spray, carbon dioxide.
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Explosion
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Above 58°C explosive vapour/air mixtures may be formed.
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Above 58°C use a closed system, ventilation.
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In case of fire: keep drums, etc., cool by spraying with water.
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Exposure
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PREVENT GENERATION OF MISTS!
AVOID Exposure OF (PREGNANT) WOMEN!
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•Inhalation
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Abdominal pain.
Diarrhoea.
Nausea.
Vomiting.
Facial flushing.
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Ventilation, local exhaust, or breathing protection.
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Fresh air, rest.
Refer for medical attention.
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•Skin
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MAY BE ABSORBED!
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Protective gloves.
Protective clothing.
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Remove contaminated clothes.
Rinse and then wash skin with water and soap.
Refer for medical attention.
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•Eyes
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Redness.
Pain.
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Safety goggles
or
eye protection in combination with breathing protection.
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First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
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•Ingestion
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Do not eat, drink, or smoke during work.
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Rinse mouth.
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Spillage Disposal
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Storage
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Packaging & Labelling
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Personal protection: complete protective clothing including self-contained breathing apparatus.
Ventilation.
Remove all ignition sources.
Collect leaking and spilled liquid in sealable containers as far as possible.
Absorb remaining liquid in sand or inert absorbent and remove to safe place.
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Separated from
strong oxidants,
halogens
.
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Note: E
T symbol
R: 61-20/21-36
S: 53-45
UN Hazard Class: 3
UN Packing Group: III
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Important Data
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Physical State; Appearance:
COLOURLESS
TO YELLOW
LIQUID
, WITH CHARACTERISTIC ODOUR.
Physical Dangers:
Chemical Dangers:
The substance decomposes
on heating
or
on burning
producing
toxic fumes
including
nitrogen oxides
.
Reacts violently withoxidants, nitrates and halogenated hydrocarbons.
Attacks some plastic and rubber.
Occupational Exposure Limits:
TLV: 10 ppm as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2004).
MAK: 5 ppm, 15 mg/m3
Peak limitation category: II(4);
skin absorption (H);
Pregnancy risk group: B;
(DFG 2005).
OSHA PEL: TWA 10 ppm (30 mg/m3) skin
NIOSH REL: TWA 10 ppm (30 mg/m3) skin
NIOSH IDLH: 500 ppm See: 68122
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Routes of Exposure:
The substance can be absorbed into the body
by inhalation
and
through the skin.
Inhalation Risk:
A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C.
Effects of Short-Term Exposure:
The substance
is irritating to
the eyes
.
The substance may cause effects on the
liver
, resulting in
jaundice
.
See Notes.
Effects of Long-Term or Repeated Exposure:
The substance may have effects on the
liver
, resulting in
impaired functions
.
Animal tests show that this substance possibly causes toxic effects upon human reproduction.
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Physical
Properties
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Boiling point: 153°C
Melting point: -61°C
Relative density (water = 1): 0.95
Solubility in water:
miscible
Vapour pressure, Pa at 25°C: about 492
Relative vapour density (air = 1): 2.5
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Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point:
58°C c.c.
Auto-ignition temperature: 445°C
Explosive limits, vol% in air: 2.2-15.2 at 100°C
Octanol/water partition coefficient as log Pow: -0.87
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Environmental
Data
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N O T E S
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Use of alcoholic beverages enhances the harmful effect.
Resulting symptoms could be delayed from several hours up to several days.
Environmental effects from the substance have been investigated but none have been found.
Card has been partly updated in October 2005. See sections Occupational Exposure Limits, Emergency Response.
Transport Emergency Card: TEC (R)-30S2265 or 30GF1-III
NFPA Code: H1; F2; R0;
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ADDITIONAL INFORMATION
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ICSC: 0457
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N,N-DIMETHYLFORMAMIDE
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(C) IPCS, CEC, 1994
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IMPORTANT LEGAL NOTICE:
Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH,
the CEC or the IPCS is responsible for the use which might be made of this
information. This card contains the collective views of the IPCS Peer Review Committee and may
not reflect in all cases all the detailed requirements included in national legislation
on the subject. The user should verify compliance of the cards with the relevant legislation
in the country of use.
The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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