1,3,7-Trimethylxanthine
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
Methyltheobromine
Methyltheophylline
C8H10N4O2
Molecular mass: 194.19
ICSC # 0405
CAS # 58-08-2
RTECS # EV6475000
UN # 1544
EC # 613-086-00-5
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Types of Hazard/ Exposure
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Acute Hazards/ Symptoms
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Prevention
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First Aid/
Fire Fighting
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FIRE
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Combustible.
Gives off irritating or toxic fumes (or gases) in a fire.
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NO open flames.
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Water spray, powder.
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Explosion
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Exposure
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PREVENT DISPERSION OF DUST!
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•Inhalation
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(See Ingestion).
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Local exhaust or breathing protection.
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Fresh air, rest.
Refer for medical attention.
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•Skin
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Protective gloves.
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Remove contaminated clothes.
Rinse skin with plenty of water or shower.
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•Eyes
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Safety spectacles.
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First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
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•Ingestion
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Headache.
Dizziness.
Abdominal cramps.
Nausea.
Vomiting.
Convulsions.
Tremors.
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Do not eat, drink, or smoke during work.
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Rinse mouth.
Give a slurry of activated charcoal in water to drink.
Induce vomiting (ONLY IN CONSCIOUS PERSONS!).
Refer for medical attention.
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Spillage Disposal
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Storage
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Packaging & Labelling
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Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting.
Carefully collect remainder,
then remove to safe place.
Personal protection: P2 filter respirator for harmful particles.
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Separated from
food and feedstuffs
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Well closed.
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Do not transport with food and feedstuffs.
Xn symbol
R: 22
S: 2
UN Hazard Class: 6.1
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Important Data
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Physical State; Appearance:
ODOURLESS
WHITE
CRYSTALS
OR CRYSTALLINE POWDER.
Physical Dangers:
Chemical Dangers:
The substance decomposes
on burning
producing
toxic fumes
including
nitrogen oxides
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Occupational Exposure Limits:
TLV not established.
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Routes of Exposure:
The substance can be absorbed into the body
by inhalation
and
by ingestion.
Inhalation Risk:
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on dust forming.
Effects of Short-Term Exposure:
The substance may cause effects on the central nervous system and cardiovascular system
, resulting in insomnia, excitement, tachycardia, polyuria.
Effects of Long-Term or Repeated Exposure:
Animal tests show that this substance possibly causes toxic effects upon human reproduction.
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Physical
Properties
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Sublimation point: 178°C
Melting point: 238°C
Density: 1.23
g/cm3
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Solubility in water, g/100 ml: 2.17
Octanol/water partition coefficient as log Pow: -0.07
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Environmental
Data
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N O T E S
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Card has been partly updated in October 2005. See section Emergency Response.
Transport Emergency Card: TEC (R)-61GT2-III
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ADDITIONAL INFORMATION
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ICSC: 0405
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CAFFEINE
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(C) IPCS, CEC, 1994
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IMPORTANT LEGAL NOTICE:
Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH,
the CEC or the IPCS is responsible for the use which might be made of this
information. This card contains the collective views of the IPCS Peer Review Committee and may
not reflect in all cases all the detailed requirements included in national legislation
on the subject. The user should verify compliance of the cards with the relevant legislation
in the country of use.
The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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