p-Nitroaniline
1-Amino-4-nitrobenzene
C.I. 37035
C6H6N2O2
Molecular mass: 138.1
ICSC # 0308
CAS # 100-01-6
RTECS # BY7000000
UN # 1661
EC # 612-012-00-9
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Types of Hazard/ Exposure
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Acute Hazards/ Symptoms
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Prevention
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First Aid/
Fire Fighting
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FIRE
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Combustible.
Many reactions may cause fire or explosion.
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NO open flames.
NO contact with combustible substances.
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Powder, water spray, foam, carbon dioxide.
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Explosion
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Finely dispersed particles form explosive mixtures in air.
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Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting.
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In case of fire: keep drums, etc., cool by spraying with water.
Combat fire from a sheltered position.
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Exposure
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PREVENT DISPERSION OF DUST!
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•Inhalation
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Blue lips or finger nails.
Blue skin.
Headache.
Dizziness.
Nausea.
Confusion.
Convulsions.
Laboured breathing.
Unconsciousness.
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Local exhaust or breathing protection.
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Fresh air, rest.
Artificial respiration if indicated.
Refer for medical attention.
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•Skin
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MAY BE ABSORBED!
(Further see Inhalation).
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Protective gloves.
Protective clothing.
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Remove contaminated clothes.
Rinse skin with plenty of water or shower.
Refer for medical attention.
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•Eyes
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Redness.
Pain.
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Face shield,
or eye protection in combination with breathing protection.
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First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
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•Ingestion
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(Further see Inhalation).
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Do not eat, drink, or smoke during work.
Wash hands before eating.
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Induce vomiting (ONLY IN CONSCIOUS PERSONS!).
Refer for medical attention.
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Spillage Disposal
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Storage
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Packaging & Labelling
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Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting.
Wash away remainder with plenty of water.
(Extra personal protection: P3 filter respirator for toxic particles.)
Do NOT let this chemical enter the environment.
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Separated from
strong acids,
strong oxidants,
combustible and reducing substances,
food and feedstuffs
.
Dry.
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Do not transport with food and feedstuffs.
Note: C
T symbol
R: 23/24/25-33-52/53
S: 1/2-28-36/37-45-61
UN Hazard Class: 6.1
UN Packing Group: II
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Important Data
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Physical State; Appearance:
YELLOW
CRYSTALS
OR POWDER.
Physical Dangers:
Dust explosion possible if in powder or granular form, mixed with air.
Chemical Dangers:
May explode on heating.
On combustion, forms toxic fumes of nitrogen oxides.
Reacts
with
strong acids
,
strong oxidants
and
strong reducing agents
.
Reacts with organic materials in presence of moisture
causing fire hazard.
Occupational Exposure Limits:
TLV: 3 mg/m3
(as TWA)
(skin) A4 (not classifiable as a human carcinogen); BEI issued (ACGIH 2005).
MAK: skin absorption (H);
Carcinogen category: 3A
(DFG 2005).
OSHA PEL: TWA 6 mg/m3 (1 ppm) skin
NIOSH REL: TWA 3 mg/m3 skin
NIOSH IDLH: 300 mg/m3 See: 100016
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Routes of Exposure:
The substance can be absorbed into the body
by inhalation of its vapour,
through the skin
and
by ingestion.
Inhalation Risk:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.
Effects of Short-Term Exposure:
The substance
is mildly irritating to
the eyes
.
The substance may cause effects on the
blood
, resulting in
formation of methaemoglobin.
The effects may be delayed.
Medical observation is indicated.
See Notes.
Effects of Long-Term or Repeated Exposure:
The substance may have effects on the
blood
, resulting in the
formation of methaemoglobin.
See Notes.
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Physical
Properties
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Boiling point: 332°C
Melting point: 148°C
Density: 1.4
g/cm3
Solubility in water, g/100 ml at 18.5°C: 0.08
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Vapour pressure, Pa at 20°C: 0.2
Relative vapour density (air = 1): 4.8
Flash point: 199°C
Octanol/water partition coefficient as log Pow: 2.66
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Environmental
Data
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The substance is harmful to aquatic organisms.
Do not let this chemical enter the environment.
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N O T E S
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Depending on the degree of exposure, periodic medical examination is indicated.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Also consult ICSC 0306 2-Nitroaniline, and ICSC 0307 3-Nitroaniline.
Transport Emergency Card: TEC (R)-61G12b
NFPA Code: H 3; F 1; R 2;
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ADDITIONAL INFORMATION
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ICSC: 0308
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4-NITROANILINE
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(C) IPCS, CEC, 1994
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IMPORTANT LEGAL NOTICE:
Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH,
the CEC or the IPCS is responsible for the use which might be made of this
information. This card contains the collective views of the IPCS Peer Review Committee and may
not reflect in all cases all the detailed requirements included in national legislation
on the subject. The user should verify compliance of the cards with the relevant legislation
in the country of use.
The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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