Diphenylmethane-4.4'-diisocyanate
bis(1,4-Isocyanatophenyl)methane
MDI
4,4'-Methylenediphenyldiisocyanate
C15H10N2O2 / OCNC6H4CH2C6H4NCO
Molecular mass: 250.3
ICSC # 0298
CAS # 101-68-8
RTECS # NQ9350000
EC # 615-005-00-9
|
|
Types of Hazard/ Exposure
|
Acute Hazards/ Symptoms
|
Prevention
|
First Aid/
Fire Fighting
|
|
FIRE
|
Combustible.
Gives off irritating or toxic fumes (or gases) in a fire.
|
NO open flames.
|
Powder, carbon dioxide.
|
|
Explosion
|
|
|
|
|
|
|
Exposure
|
|
AVOID ALL CONTACT!
|
IN ALL CASES CONSULT A DOCTOR!
|
|
•Inhalation
|
Headache.
Nausea.
Shortness of breath.
Sore throat.
|
Local exhaust or breathing protection.
|
Fresh air, rest.
Artificial respiration may be needed.
Refer for medical attention.
|
|
•Skin
|
Redness.
|
Protective gloves.
Protective clothing.
|
Remove contaminated clothes.
Rinse skin with plenty of water or shower.
Refer for medical attention.
|
|
•Eyes
|
Pain.
|
Safety goggles
or
face shield
.
|
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
|
|
•Ingestion
|
|
Do not eat, drink, or smoke during work.
|
Rinse mouth.
Do NOT induce vomiting.
Refer for medical attention.
|
|
Spillage Disposal
|
Storage
|
Packaging & Labelling
|
Evacuate danger area!
Consult an expert!
Chemical protection suit including self-contained breathing apparatus.
Sweep spilled substance into sealable containers.
Carefully collect remainder,
then remove to safe place.
|
Separated from
food and feedstuffs
,
incompatible materials
.
See Chemical Dangers.
Cool.
Dry.
Keep in the dark.
|
Unbreakable packaging; put breakable packaging into closed unbreakable container.
Do not transport with food and feedstuffs.
Note: C
Xn symbol
R: 20-36/37/38-42/43
S: 1/2-23-36/37-45
|
|
|
|
Important Data
|
Physical State; Appearance:
WHITE
TO PALE YELLOW CRYSTALS
OR FLAKES.
Physical Dangers:
Chemical Dangers:
The substance may polymerize
under the influence of temperatures above 204°C.
On combustion, forms toxic and corrosive fumes including nitrogen oxides and hydrogen cyanide (see ICSC 0492).
Reacts readily with water to form insoluble polyureas.
Reacts
violently with
acids
,
alcohols
,
amines
,
bases
and
oxidants
causing fire and explosion hazard.
Occupational Exposure Limits:
TLV: 0.005 ppm as TWA; (skin); (ACGIH 2004).
MAK: (Inhalable fraction) 0.05 mg/m3
Peak limitation category: I(1);
sensitization of respiratory tract and skin (Sah);
Carcinogen category: 3B; Pregnancy risk group: D;
(DFG 2006).
OSHA PEL: C 0.2 mg/m3 (0.02 ppm)
NIOSH REL: TWA 0.05 mg/m3 (0.005 ppm) C 0.2 mg/m3 (0.020 ppm) 10-minute
NIOSH IDLH: 75 mg/m3 See: 101688
|
Routes of Exposure:
The substance can be absorbed into the body
by inhalation.
Inhalation Risk:
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed.
Effects of Short-Term Exposure:
Tear drawing.
The substance
irritates
the eyes,
the skin
and
the respiratory tract.
The substance may cause effects on the
lungs
, resulting in
impaired functions
.
Effects of Long-Term or Repeated Exposure:
Repeated or prolonged contact may cause skin sensitization.
Repeated or prolonged inhalation exposure may cause asthma (see Notes).
|
|
Physical
Properties
|
Boiling point at 100 kPa: 314°C
Melting point: 37°C
Relative density (water = 1): 1.2
Solubility in water:
reaction
|
Vapour pressure, Pa at 20°C:
negligible
Relative vapour density (air = 1): 8.6
Flash point: 196°C c.c.
Auto-ignition temperature: 240°C
|
|
Environmental
Data
|
|
|
N O T E S
|
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.
MDI may sensitize workers so that they react to other isocyanates (asthma).
Do NOT take working clothes home.
Caradate 30, Desmodur 44, Hylene M 150, Isonate, Nacconate 300, NCI-C50668, Rubinate 44 are trade names.
Card has been partially updated in July 2007: see Occupational Exposure Limits.
|
|
|
ADDITIONAL INFORMATION
|
|
|
|
ICSC: 0298
|
METHYLENE BISPHENYL ISOCYANATE
|
|
(C) IPCS, CEC, 1994
|
|
|
IMPORTANT LEGAL NOTICE:
Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH,
the CEC or the IPCS is responsible for the use which might be made of this
information. This card contains the collective views of the IPCS Peer Review Committee and may
not reflect in all cases all the detailed requirements included in national legislation
on the subject. The user should verify compliance of the cards with the relevant legislation
in the country of use.
The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
|
|
|