Hexamethylphosphoramide
Hexamethylphosphamide
HMPA
C6H18N3OP / {(CH3)2N}3P(O)
Molecular mass: 179.2
ICSC # 0162
CAS # 680-31-9
RTECS # TD0875000
EC # 015-106-00-2
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Types of Hazard/ Exposure
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Acute Hazards/ Symptoms
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Prevention
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First Aid/
Fire Fighting
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FIRE
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Combustible.
Gives off irritating or toxic fumes (or gases) in a fire.
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NO open flames.
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Powder, alcohol-resistant foam, water spray, carbon dioxide.
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Explosion
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Exposure
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AVOID ALL CONTACT!
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IN ALL CASES CONSULT A DOCTOR!
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•Inhalation
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Ventilation, local exhaust, or breathing protection.
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Refer for medical attention.
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•Skin
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MAY BE ABSORBED!
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Protective gloves.
Protective clothing.
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Remove contaminated clothes.
Rinse and then wash skin with water and soap.
Refer for medical attention.
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•Eyes
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Safety spectacles
or
face shield
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First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
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•Ingestion
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Do not eat, drink, or smoke during work.
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Rinse mouth.
Refer for medical attention.
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Spillage Disposal
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Storage
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Packaging & Labelling
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Collect leaking and spilled liquid in sealable containers as far as possible.
Absorb remaining liquid in sand or inert absorbent and remove to safe place.
Personal protection: self-contained breathing apparatus.
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Ventilation along the floor.
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T symbol
R: 45-46
S: 53-45
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Important Data
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Physical State; Appearance:
COLOURLESS
MOBILE LIQUID.
Physical Dangers:
Chemical Dangers:
The substance decomposes
on heating
or
on burning
producing
toxic fumes
including
phosphorus oxides
nitrogen oxides
.
Occupational Exposure Limits:
TLV: A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2004).
MAK: skin absorption (H);
Carcinogen category: 2;
(DFG 2004).
OSHA PEL: none
NIOSH REL: Ca See Appendix A
NIOSH IDLH: Ca N.D. See: IDLH INDEX
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Routes of Exposure:
The substance can be absorbed into the body
by inhalation
and
through the skin.
Inhalation Risk:
No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C.
Effects of Short-Term Exposure:
The substance may cause effects on the
lungs
,
kidneys
and
central nervous system
, resulting in impaired functions and depression.
Effects of Long-Term or Repeated Exposure:
The substance may have effects on the respiratory tract,kidneysandbone marrow.
This substance is possibly carcinogenic to humans.
May cause genetic damage in humans.
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Physical
Properties
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Boiling point: 232°C
Melting point: 5-7°C
Relative density (water = 1): 1.03
Solubility in water: very good
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Vapour pressure, Pa at 20°C: 4
Relative vapour density (air = 1): 6.18
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 105°C
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Environmental
Data
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N O T E S
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Depending on the degree of exposure, periodic medical examination is suggested.
Hexametapol is a trade name.
Card has been partly updated in April 2005. See section Occupational Exposure Limits.
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ADDITIONAL INFORMATION
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ICSC: 0162
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HEXAMETHYLPHOSPHORIC TRIAMIDE
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(C) IPCS, CEC, 1994
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IMPORTANT LEGAL NOTICE:
Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH,
the CEC or the IPCS is responsible for the use which might be made of this
information. This card contains the collective views of the IPCS Peer Review Committee and may
not reflect in all cases all the detailed requirements included in national legislation
on the subject. The user should verify compliance of the cards with the relevant legislation
in the country of use.
The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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