o-Chloronitrobenzene
o-Nitrochlorobenzene
1-Chloro-2-nitrobenzene
C6H4ClNO2
Molecular mass: 157.6
ICSC # 0028
CAS # 88-73-3
RTECS # CZ0875000
UN # 1578
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Types of Hazard/ Exposure
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Acute Hazards/ Symptoms
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Prevention
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First Aid/
Fire Fighting
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FIRE
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Combustible.
Many reactions may cause fire or explosion.
Gives off irritating or toxic fumes (or gases) in a fire.
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NO open flames.
NO contact with flammable substances.
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Powder, water spray, foam, carbon dioxide.
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Explosion
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Finely dispersed particles form explosive mixtures in air.
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Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting.
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Exposure
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PREVENT DISPERSION OF DUST!
STRICT HYGIENE!
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•Inhalation
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Blue lips or finger nails.
Blue skin.
Dizziness.
Headache.
Nausea.
Shortness of breath.
Confusion.
Convulsions.
Unconsciousness.
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Local exhaust or breathing protection.
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Fresh air, rest.
Artificial respiration may be needed.
Refer for medical attention.
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•Skin
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MAY BE ABSORBED!
(Further see Inhalation).
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Protective gloves.
Protective clothing.
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First rinse with plenty of water, then remove contaminated clothes and rinse again.
Refer for medical attention.
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•Eyes
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Redness.
Pain.
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Safety goggles
or
eye protection in combination with breathing protection.
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First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
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•Ingestion
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(See Inhalation).
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Do not eat, drink, or smoke during work.
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Rinse mouth.
Give a slurry of activated charcoal in water to drink.
Refer for medical attention.
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Spillage Disposal
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Storage
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Packaging & Labelling
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Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting.
Carefully collect remainder,
then remove to safe place.
Do NOT absorb in saw-dust or other combustible absorbents.
Do NOT let this chemical enter the environment.
Personal protection: complete protective clothing including self-contained breathing apparatus.
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Separated from
combustible and reducing substances,
food and feedstuffs
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Do not transport with food and feedstuffs.
UN Hazard Class: 6.1
UN Packing Group: II
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Important Data
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Physical State; Appearance:
YELLOW
TO GREEN
CRYSTALS
, WITH CHARACTERISTIC ODOUR.
Physical Dangers:
Dust explosion possible if in powder or granular form, mixed with air.
Chemical Dangers:
The substance decomposes
on burning
producing
toxic and corrosive fumes
(
nitrogen oxides
,
chlorine
- see ICSC0126,
hydrogen chloride
- see ICSC0163,
phosgene
- see ICSC0007).
The substance is a strong oxidant and reacts with combustible and reducing materials.
Occupational Exposure Limits:
TLV not established. (See Notes).
BEI issued
MAK: skin absorption (H);
Carcinogen category: 3B;
(DFG 2004).
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Routes of Exposure:
The substance can be absorbed into the body
by inhalation,
through the skin
and
by ingestion.
Inhalation Risk:
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.
Effects of Short-Term Exposure:
The substance
is mildly irritating to
the eyes
.
The substance may cause effects on the
blood
, resulting in
the formation of methaemoglobin.
The effects may be delayed.
Medical observation is indicated.
See Notes.
Effects of Long-Term or Repeated Exposure:
The substance may have effects on the
blood
and
liver
, resulting in
the formation of methaemoglobin,
anaemia
and
liver impairment
.
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Physical
Properties
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Boiling point: 246°C
Melting point: 33°C
Density: 1.4
g/cm3
Solubility in water: none
Vapour pressure, kPa at 20°C: 0.6
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Relative vapour density (air = 1): 5.4
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.03
Flash point: 124°C c.c.
Auto-ignition temperature: 487°C
Explosive limits, vol% in air: 1.15-13.1
Octanol/water partition coefficient as log Pow: 2.24
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Environmental
Data
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The substance is harmful to aquatic organisms.
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N O T E S
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TLV (as para-nitrochlorobenzene): 0.1 ppm (skin) A3 (confirmed animal carcinogen with unknown relevance to humans) (ACGIH 2004).
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Rinse contaminated clothes (fire hazard) with plenty of water.
Card has been partly updated in April 2005. See section Occupational Exposure Limits.
Transport Emergency Card: TEC (R)-61S1578-S
NFPA Code: H3; F1; R1;
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ADDITIONAL INFORMATION
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ICSC: 0028
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2-CHLORO-1-NITROBENZENE
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(C) IPCS, CEC, 1994
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IMPORTANT LEGAL NOTICE:
Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH,
the CEC or the IPCS is responsible for the use which might be made of this
information. This card contains the collective views of the IPCS Peer Review Committee and may
not reflect in all cases all the detailed requirements included in national legislation
on the subject. The user should verify compliance of the cards with the relevant legislation
in the country of use.
The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.
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